Concepedia

Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1 S,2 S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents

Tung M. Fong, Xiao-Ming Guan, Donald J. Marsh, Chun-Pyn Shen, D. Sloan Stribling, Kim Rosko, Julie Lao, Hong Yu, Yue Feng, Jing Chen Xiao,

Journal of Pharmacology and Experimental Therapeutics · 2007 · 101 citations · 30 references

DOI

Concepts

References

30

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

Murielle Rinaldi‐Carmona, Francis Barth, Michel Héaulme et al. · FEBS Letters · 1994 · 1.8K citations · Full text

, , +14

Leptin-regulated endocannabinoids are involved in maintaining food intake

Vincenzo Di Marzo, Sravan K. Goparaju, Lei Wang et al. · Nature · 2001 · 1.6K citations

, , +12

Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

Luc F. Van Gaal, Aila Rissanen, André Scheen et al. · The Lancet · 2005 · 1.5K citations · Full text

, , +16

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

Daniela Cota, Giovanni Marsicano, Matthias H. Tschöp et al. · Journal of Clinical Investigation · 2003 · 1.1K citations · Full text

, , +16

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

Andreas Zimmer, Anne Zimmer, Andrea G. Hohmann et al. · Proceedings of the National Academy of Sciences · 1999 · 1.1K citations

, , +9