Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells

Abstract

Key Points Wnt/β-catenin signaling increases ETO and Runx1 transcription in human hematopoietic progenitors. Wnt/β-catenin signaling enhances spatial proximity of ETO and RUNX1 genes and induces the generation of a recurrent translocation event.