Concepedia

Expression and prognostic significance of the oncogenic K2P potassium channel KCNK9 (TASK-3) in ovarian carcinoma.

Anni Innamaa, Leigh Jackson, Viren Asher, Gerhard Van Shalkwyk, Averil Y. Warren, Daniel Hay, Anish Bali, Heidi Sowter, Raheela Khan

PubMed · 2013 · 44 citations · 25 references

Abstract

TASK-3 is expressed in epithelial ovarian cancer, conferring a significant survival advantage on patients with increased expression. TASK-3-modulating agents have a significant effect on cell proliferation and apoptosis. Based on these results, we propose that TASK-3 could prove to be both a novel tumour marker and a new therapeutic target in ovarian cancer, but further investigation is required.

References

25

Tissue microarrays for high-throughput molecular profiling of tumor specimens

Juha Kononen, Lukas Bubendorf, Anne Kallionimeni et al. · Nature Medicine · 1998 · 4.1K citations

Engineering, Tumor Heterogeneity, Computational Biology +6

Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene

David Mu, Liyun Chen, Xiping Zhang et al. · Cancer Cell · 2003 · 260 citations · Full text

Genomic Amplification, Signal Transduction, Hyperpolarization (Biology) +10

HERG K+ channel, a regulator of tumor cell apoptosis and proliferation.

Huizhen Wang, Yiqiang Zhang, Liwen Cao et al. · PubMed · 2002 · 229 citations

Cardiac Muscle, Herg K+ Channel, Apoptosis +21

Potassium channels and regulation of proliferation of human melanoma cells.

Bernd Nilius, W Wohlrab · The Journal of Physiology · 1992 · 203 citations · Full text

Localisation and Function of the Endocannabinoid System in the Human Ovary

Mona R. El-Talatini, Anthony H. Taylor, J. Elson et al. · PLoS ONE · 2009 · 178 citations · Full text