Concepedia

Active Human Nucleolar Organizer Regions are Interspersed with Inactive rDNA Repeats in Normal and Tumor Cells

Karina Zillner, Jun Komatsu, Katharina Filarsky, Rajakiran Kalepu, Aaron Bensimon, Attila Németh

Epigenomics · 2015 · 29 citations · 34 references

DOIFull text

Open access

Abstract

Collectively, our analyses revealed co-existence of different epialleles on individual nucleolar organizer regions and showed that epi-combing is a valuable approach to analyze epigenomic patterns of repetitive DNA.

References

34

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Benjamin A. Flusberg, Dale R. Webster, Jessica H. Lee et al. · Nature Methods · 2010 · 1.5K citations · Full text

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Repetitive Elements May Comprise Over Two-Thirds of the Human Genome

A. P. Jason de Koning, Wanjun Gu, Todd A. Castoe et al. · PLoS Genetics · 2011 · 1.1K citations · Full text

Alignment and Sensitive Detection of DNA by a Moving Interface

Aaron Bensimon, Adam Simon, A. Chiffaudel et al. · Science · 1994 · 835 citations

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

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Megan J. Bywater, Gretchen Poortinga, Elaine Sanij et al. · Cancer Cell · 2012 · 552 citations · Full text