Iron‐Catalyzed Acylative Dealkylation of <i>N</i>‐Alkylsulfoximines

Abstract

Abstract As a result of our recent investigations into the N‐functionalization of sulfoximines, an iron‐catalyzed dealkylative acylation of N ‐alkylsulfoximines has been developed. This process involves a Polonovski‐type dealkylation of an N ‐alkylated sulfoximine to afford a reactive intermediate that is trapped in the presence of a suitable aldehyde or anhydride to afford N ‐acyl‐ and N ‐aroylsulfoximine derivatives in one pot. Subsequent cleavage of the acyl or aroyl group under acidic conditions generates a synthetically valuable N H‐sulfoximine.