Relevance of Arteriovenous Concentration Differences in Pharmacokinetic-Pharmacodynamic Modeling of Midazolam

Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to <i>d</i>‐tubocurarine

Lewis B. Sheiner, Donald R. Stanski, Samuel Vožeh et al. · Clinical Pharmacology & Therapeutics · 1979 · 1.1K citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite α-hydroxymidazolam in healthy volunteers

Jaap W Mandona, Bert Tuk, Alfred L van Steveninck et al. · Clinical Pharmacology & Therapeutics · 1992 · 228 citations

Medicine, Pharmacokinetics, Pharmacology +14

Simultaneous Modeling of Pharmacokinetics and Pharmacodynamics with a Nonparametric Pharmacodynamic Model

Eliane Fuseau, Lewis B. Sheiner · Clinical Pharmacology & Therapeutics · 1984 · 145 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacology +13

Pharmacodynamic modeling of thiopental anesthesia

Donald R. Stanski, Robert J. Hudson, Terri D. Homer et al. · Journal of Pharmacokinetics and Biopharmaceutics · 1984 · 99 citations

Medicine, Anesthesiology, Pharmacology +11

Kinetics of interaction between drugs and biological systems.

G Segré · PubMed · 1968 · 93 citations

Pharmacy, Pharmacokinetics, Pharmacology +12