Epileptic Disorders · 2013 · 12 citations · 20 references
MedicineGeneticsMolecular GeneticsEpilepsyInflammationPharmacogeneticsDrug-resistant EpilepsyEpilepsy GeneticsEpilepsy In ChildhoodEtiology Of EpilepsyGenetic EpilepsiesDrug-resistant Epilepsy GeneticsEtiology Of Childhood EpilepsyGenetic Causes Of EpilepsyGenetic Epilepsies In ChildrenPediatric Drug-resistant EpilepsyPharmacogenetics In EpilepsyRefractory Epilepsy Treatment
The treatment of drug-resistant epilepsy remains a major challenge, affecting approximately 30% of epilepsy patients. More recently, immunity and inflammation are considered to be key elements of epilepsy. Targeting brain inflammation may represent a novel therapeutic strategy for epilepsy and refractory epilepsy. In this study, we investigated the association of a tag SNP of the CCL2 gene, rs1024611 (originally designated as -2578G>A or -2518G>A) with drug-resistant epilepsy in Chinese children with epilepsy. We enrolled 484 epilepsy patients, including 98 drug-resistant patients and 386 drug-responsive patients. The rs1024611 was genotyped by PCR-RPLP. The rs1024611 AA genotype was associated with a greater susceptibility to drug-resistant epilepsy (p=0.008; OR=2.51, 95% CI: 1.33-4.72), adjusted for age, sex, and seizure type, and the association remained significant after Bonferroni correction for multiple testing (p<0.05). Our results demonstrate that the CCL2 genetic polymorphism is associated with drug-resistant epilepsy in Chinese paediatric patients.
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