Concepedia

Phenylpiperidine‐type γ‐secretase modulators target the transmembrane domain 1 of presenilin 1

Yu Ohki, Takuya Higo, Kengo Uemura, Naoaki Shimada, Satoko Osawa, Oksana Berezovska, Satoshi Yokoshima, Tohru Fukuyama, Taisuke Tomita, Takeshi Iwatsubo

The EMBO Journal · 2011 · 112 citations · 39 references

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39

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Takeshi Iwatsubo, Asano Odaka, Nobuhiro Suzuki et al. · Neuron · 1994 · 1.8K citations

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A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Sascha Weggen, Jason L. Eriksen, Pritam Das et al. · Nature · 2001 · 1.4K citations

, , +14

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Yue‐Ming Li, Min Xu, Ming‐Tain Lai et al. · Nature · 2000 · 869 citations

, , +14

The role of presenilin cofactors in the γ-secretase complex

Nobumasa Takasugi, Taisuke Tomita, Ikuo Hayashi et al. · Nature · 2003 · 867 citations

, , +10

Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics

Toshio Kitamura, Yuko Koshino, Fumi Shibata et al. · Experimental Hematology · 2003 · 678 citations

, , +17