Concepedia

Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis

Hai Zhang, Yong Guo, W. Wang, Mei Shi, Xingfei Chen, Zhirong Yao

Allergy · 2010 · 81 citations · 28 references

DOI

Abstract

Our study increases the total number of reported FLG mutations. Moreover, we further confirm that FLG mutations are strong predisposing factors for AD in Han Chinese.

References

28

Diagnostic Features of Atopic Dermatitis

Jon M. Hanifin, Georg Rajka · Acta Dermato Venereologica · 1980 · 5.1K citations · Full text

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Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 2.9K citations

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Severity Scoring of Atopic Dermatitis: The SCORAD Index

Dermatology · 1993 · 2.3K citations

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Frances J.D. Smith, Alan D. Irvine, Ana Terron-Kwiatkowski et al. · Nature Genetics · 2006 · 1K citations

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Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

Aileen Sandilands, Ana Terron-Kwiatkowski, Peter Hull et al. · Nature Genetics · 2007 · 660 citations

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