Effects of butyrate on histone deacetylation and aldosterone-dependent Na+ transport in the toad bladder.

Abstract

Sodium butyrate effectively inhibited histone deacetylation in the toad bladder of Bufo marinus in vitro.The inhibition was dose-dependent (Ki = 0.95 m ~) and reversible.Incubation of tissue with 3 m~ butyrate for 4 h induced hyperacetylation of histones, especially of H4, H2B, and H3.The inhibitory activity of related analogues was: butyrate z propionate > isobutyrate.