Editor's Note: Inhibition of Platelet-derived Growth Factor–mediated Proliferation of Osteosarcoma Cells by the Novel Tyrosine Kinase Inhibitor STI571

Abstract

Our data demonstrate that STI571 inhibits PDGF-mediated growth and leads to apoptosis of osteosarcoma cells in vitro by selective inhibition of the PDGFR tyrosine kinase. The effectiveness of STI571 in our studies suggests targeting of PDGFRs as a novel treatment for osteosarcoma.