Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituentsElectronic supplementary information (ESI) available: 1H and 13C NMR data for compounds 5–8. See http://www.rsc.org/suppdata/cc/b2/b200536k/ - Concepedia

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Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituentsElectronic supplementary information (ESI) available: 1H and 13C NMR data for compounds 5–8. See http://www.rsc.org/suppdata/cc/b2/b200536k/

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Citations

5

References

2002

Year

Sabine Gaisser, Christine Martin, Barrie Wilkinson, Rose Sheridan, Rachel E. Lill, Alison J. Weston, Sarah Ready, Clive Waldron, Gary D. Crouse, Peter F. Leadlay,

Chemical Communications

Bioorganic ChemistryEngineeringGlycobiologyMolecular BiologyNovel Spinosyns BearingBeta-d-forosamine MoietyChemical BiologyRedox BiologyNovel SpinosynsBiosynthesisMetabolic EngineeringNatural Product BiosynthesisCompounds 5–8GlycosylationBiotransformationBiochemistryHydroxy GroupBiocatalysisBiomolecular EngineeringNmr DataNatural SciencesBiotechnologySynthetic BiologyDeoxygenation

Abstract

Novel spinosyns have been prepared by biotransformation, using a genetically engineered strain of Saccharopolyspora erythraea, in which the beta-D-forosamine moiety in glycosidic linkage to the hydroxy group at C17 is replaced by alpha-L-mycarose.

References

	Year	Citations

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