Loss of Heterozygosity and Microsatellite Instability in Acquired Melanocytic Nevi: Towards a Molecular Definition of the Dysplastic Nevus

Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

J L Weber, Paula E. May · PubMed · 1989 · 3.4K citations

Life Sciences, Genetics, Molecular Genetics +14

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

Yurij Ionov, Miguel A. Peinado, Sergei Malkhosyan et al. · Nature · 1993 · 2.7K citations

Medicine, Genetics, Molecular Genetics +17

Origin of Familial Malignant Melanomas From Heritable Melanocytic Lesions

Wallace H. Clark · Archives of Dermatology · 1978 · 822 citations

Medicine, Dermatology, Pathology +17

A Mutator Phenotype in Cancer 1

Lawrence A. Loeb · 2001 · 672 citations

Medicine, Genetics, Oncology +13

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations

B. Michael Ghadimi, Dan L. Sackett, Michael J. Difilippantonio et al. · Genes Chromosomes and Cancer · 2000 · 279 citations

Life Sciences, Cell Biology, Oncology +17