Origin of Familial Malignant Melanomas From Heritable Melanocytic Lesions

TLDR

The study identified distinctive melanocytic moles in 37 patients across six melanoma families. The distinctive B‑K moles were present in 15 of 17 melanoma patients and 22 of 41 relatives, characterized by variable numbers, sizes, and colors, atypical histology, and were observed to transform into melanoma in two cases. Arch Dermatol 114:732‑738, 1978.

Abstract

• Distinctive melanocytic moles are described in 37 patients from six melanoma families. Among the family members examined by the authors, 15 of 17 patients with melanoma and 22 of 41 nonmelanoma relatives had the unique moles. The clinical and histological features of these moles have been designated the "B-K mole syndrome." The clinical features of the syndrome include the presence of &lt; 10 to &gt; 100 moles prominent on the upper trunk and extremities, and variability of mole size (5 mm to 15 mm), outline, and color combination. Histologically, B-K moles show atypical melanocytic hyperplasia, lymphocytic infiltration, delicate fibroplasia, and new blood vessels that occur within a compound nevus or de novo. The transformation of two B-K moles into malignant melanomas was documented photographically. (<i>Arch Dermatol</i>114:732-738, 1978)