Enhanced thromboxane A2 and prostacyclin production by cultured rectal mucosa in ulcerative colitis and its inhibition by steroids and sulfasalazine

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Mats Hámberg, Jan Olof Svensson, B Samuelsson · Proceedings of the National Academy of Sciences · 1975 · 3.1K citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +14

AN EXPERIMENT TO DETERMINE THE ACTIVE THERAPEUTIC MOIETY OF SULPHASALAZINE

A K Azad Khan, J Piris, S. C. Truelove · The Lancet · 1977 · 822 citations

Pharmacy, Medicinal Chemistry, Pharmacology +4

The chemical structure of prostaglandin X (prostacyclin)

Roy A. Johnson, Douglas R. Morton, John H. Kinner et al. · Prostaglandins · 1976 · 730 citations

Natural Sciences, Chemistry, Pharmacology +10