Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

Masayoshi Uehata, Toshimasa Ishizaki, Hiroyuki Satoh et al. · Nature · 1997 · 2.9K citations

Hypertension, Muscle Function, Signal Transduction +11

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

Omar A. Coso, M Chiariello, Jin‐Chen Yu et al. · Cell · 1995 · 1.6K citations · Full text

Signal Transduction, Signaling Pathway, Molecular Pathway +8

Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

Ning Zheng, Brenda A. Schulman, Langzhou Song et al. · Nature · 2002 · 1.5K citations

Structural Biology, Molecular Biology, Protein X-ray Crystallography

G12-G13–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension

Angela Wirth, Zoltán Benyó, Martina Lukasova et al. · Nature Medicine · 2007 · 672 citations

Hypertension, Signal Transduction, Molecular Physiology +13

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

Lynn M. Boyden, Murim Choi, Keith A. Choate et al. · Nature · 2012 · 625 citations

Molecular Physiology, Genetics, Physiology +7