Elastin is an essential determinant of arterial morphogenesis

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Medicine, Genetics, Molecular Genetics +15

Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome

Amanda K. Ewart, Colleen A. Morris, Donald L. Atkinson et al. · Nature Genetics · 1993 · 1.2K citations

Life Sciences, Genetics, Molecular Genetics +12

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

Kirk R. Thomas, Mario R. Capecchi · Nature · 1990 · 896 citations

Medicine, Developmental Biology, Molecular Genetics +16

Fibrillar Collagen Inhibits Arterial Smooth Muscle Proliferation through Regulation of Cdk2 Inhibitors

Hidenori Koyama, Elaine W. Raines, Karin Bornfeldt et al. · Cell · 1996 · 513 citations · Full text

Medicine, Pathology, Cytoskeleton +7

The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis

Michael A. Curran · Cell · 1993 · 423 citations

Medicine, Genetics, Molecular Genetics +13