Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

Life Sciences, Developmental Biology, Molecular Biology +12

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

Roel Nusse, Harold Varmus · Cell · 1982 · 1.9K citations

Life Sciences, Molecular Genetics, Oncology +17

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Medicine, Genetics, Molecular Genetics +15

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

Thomas M. DeChiara, Argiris Efstratiadis, Elizabeth J. Robertsen · Nature · 1990 · 1.7K citations

Medicine, Genetics, Molecular Genetics +13

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

Allan Bradley, Martin Evans, M. H. Kaufman et al. · Nature · 1984 · 1.5K citations

Life Sciences, Cell Biology, Developmental Biology +10