Concepedia

Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes

Masato Chiba, Michelle Hensleigh, J H Lin

Biochemical Pharmacology · 1997 · 129 citations · 16 references

DOI

Concepts

References

16

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

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Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

K. Sandy Pang, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1977 · 798 citations

, , +17

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

Joseph P. Vacca, Bruce D. Dorsey, William A. Schleif et al. · Proceedings of the National Academy of Sciences · 1994 · 526 citations

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Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues.

Isabelle de Waziers, Paul‐Henri Cugnenc, Chunsong Yang et al. · Journal of Pharmacology and Experimental Therapeutics · 1990 · 502 citations

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Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

Harold Boxenbaum · Journal of Pharmacokinetics and Biopharmaceutics · 1980 · 343 citations

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