Selective, potent blockade of the <scp>IRE</scp>1 and <scp>ATF</scp>6 pathways by 4‐phenylbutyric acid analogues

Abstract

The 4-PBA analogues 2-POAA-OMe, 2-POAA-NO2 and 2-NOAA strongly inhibited activation of the IRE1 and ATF6 pathways and downstream pathogenic targets, including NF-κB and Akt, in ER stress-exposed cells. These compounds may be useful for therapeutic intervention in ER stress-related pathological conditions.