Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of <scp>AMPK</scp>‐dependent autophagy

Abstract

These results provide the first evidence that acute metformin preconditioning induces autophagy by activation of brain AMPK, which confers neuroprotection against subsequent cerebral ischaemia. This suggests that metformin, a well-known hypoglycaemic drug, may have a practical clinical use for stroke prevention.