Concepedia

Generating mice with targeted mutations

Mario R. Capecchi

Nature Medicine · 2001 · 120 citations · 46 references

DOI

Concepts

References

46

Establishment in culture of pluripotential cells from mouse embryos

Martin Evans, M. H. Kaufman · Nature · 1981 · 8.6K citations

, , +14

Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults

Oliver Smithies · Biochemical Journal · 1955 · 2.8K citations · Full text

, , +11

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

, , +12

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

Richard S. Mann, Richard C. Mulligan, David Baltimore · Cell · 1983 · 1.9K citations

, , +14

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

, , +15