Concepedia

Mechanism of Acceleration of Antithrombin-Proteinase Reactions by Low Affinity Heparin

V. J. Streusand, Ingemar Björk, Peter G.W. Gettins, Maurice Petitou, Steven T. Olson

Journal of Biological Chemistry · 1995 · 95 citations · 40 references

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Abstract

resulting both from a decreased antithrombin affinity and the inability to induce a full activating conformational change in the inhibitor.

References

40

Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

J Choay, Maurice Petitou, J C Lormeau et al. · Biochemical and Biophysical Research Communications · 1983 · 650 citations

, , +7

Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement.

Steven T. Olson, Ingemar Björk, Roberta Sheffer et al. · Journal of Biological Chemistry · 1992 · 470 citations · Full text

, , +20

Further characterization of the antithrombin-binding sequence in heparin

L Thunberg, Gudrun Bäckström, Ulf Lindahl · Carbohydrate Research · 1982 · 451 citations

, , +6

Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4

David A. Lane, J. J. Denton, A. Flynn et al. · Biochemical Journal · 1984 · 344 citations · Full text

, , +22

The kinetics of hemostatic enzyme-antithrombin interactions in the presence of low molecular weight heparin.

Robert E. Jordan, G.M. Oosta, W.T. Gardner et al. · Journal of Biological Chemistry · 1980 · 335 citations · Full text

, , +16