Peter G.W. Gettins

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Å and full insertion of the reactive center loop into β-sheet A

Efstratios Stratikos, Peter G.W. Gettins · Proceedings of the National Academy of Sciences · 1999 · 213 citations

Life Sciences, Biochemistry, Molecular Biology +17

Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate

Philip A. Patston, Peter G.W. Gettins, Joe Beechem et al. · Biochemistry · 1991 · 178 citations

Medicine, Pharmacology, Molecular Pharmacology +6

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

Pasupathy Sivasothy, Timothy R. Dafforn, Peter G.W. Gettins et al. · Journal of Biological Chemistry · 2000 · 141 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

The ternary complex of antithrombin–anhydrothrombin–heparin reveals the basis of inhibitor specificity

Alexey Dementiev, Maurice Petitou, Jean‐Marc Herbert et al. · Nature Structural & Molecular Biology · 2004 · 137 citations

Life Sciences, Biochemistry, Molecular Biology +15

Active Site Distortion Is Sufficient for Proteinase Inhibition by Serpins

Alexey Dementiev, József Dobó, Peter G.W. Gettins · Journal of Biological Chemistry · 2005 · 136 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17