Concepedia

DNA hypomethylation leads to elevated mutation rates

Richard Z. Chen, Ulf Pettersson, Caroline Beard, Laurie Jackson‐Grusby, Rudolf Jaenisch

Nature · 1998 · 954 citations · 21 references

DOI

Concepts

References

21

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

En Li, Timothy H. Bestor, Rudolf Jaenisch · Cell · 1992 · 4K citations

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Mutator phenotype may be required for multistage carcinogenesis.

L A Loeb · PubMed · 1991 · 1.3K citations

, , +11

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

Marilyn Monk, Michael Boubelı́k, Sigrid A. Lehnert · Development · 1987 · 1.1K citations

, , +17

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

Hong Lei, S. Paul Oh, Masaki Okano et al. · Development · 1996 · 802 citations

, , +16

Suppression of intestinal neoplasia by DNA hypomethylation

Peter W. Laird, Laurie Jackson‐Grusby, Amin Fazeli et al. · Cell · 1995 · 714 citations · Full text

, , +14