The stomach as a site for anthocyanins absorption from food¹

TLDR

Anthocyanins may permeate gastric mucosa, explaining their rapid appearance in plasma of rats and humans. The study aimed to demonstrate stomach involvement in grape anthocyanin absorption in rats. Absorption was quantified using HPLC with diode array detection and mass spectrometry. Malvidin 3‑glucoside appeared in portal and systemic plasma within 6 min, reaching mean concentrations of 0.650 μM and 0.234 μM, respectively.

Abstract

The ability of anthocyanins to permeate the gastric mucosa can be suggested as a possible explanation of the fast kinetics of plasma appearance of anthocyanins in rats and humans. This paper presents an in vivo experiment aimed to prove the involvement of the stomach in the absorption of grape anthocyanins in rats. The required analytical selectivity and sensitivity was achieved by high‐performance liquid chromatography, diode array detection and mass spectrometry. Malvidin 3‐glucoside appeared in both portal and systemic plasma after only 6 min. The average concentrations measured in portal and systemic plasma were 0.650±0.162 μM and 0.234±0.083 μM (mean±S.E.M. ), respectively.