Enhancement of tumor necrosis factor α antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13)

An endotoxin-induced serum factor that causes necrosis of tumors.

E A Carswell, Lloyd J. Old, Robert Kassel et al. · Proceedings of the National Academy of Sciences · 1975 · 4.5K citations · Full text

Veterinary Medicine, Immunology, Pathobiology +15

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

Wadih Arap, Renata Pasqualini, Erkki Ruoslahti · Science · 1998 · 2.1K citations

Pharmacy, Oncology, Pharmacology +17

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

Peter P. Nawroth, D Stern · The Journal of Experimental Medicine · 1986 · 1.3K citations · Full text

Veterinary Medicine, Hematology, Immunology +17

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.

Renata Pasqualini, Erkki Koivunen, Renate Kain et al. · PubMed · 2000 · 867 citations

Medicine, Oncology, Pharmacology +16

αv Integrins as receptors for tumor targeting by circulating ligands

Renata Pasqualini, Erkki Koivunen, Erkki Ruoslahti · Nature Biotechnology · 1997 · 748 citations

Medicine, Cancer Biology, Oncology +12