Metabolism and Pharmacokinetics of Novel Oral Prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in Dogs

Prevention of SIV Infection in Macaques by ( <i>R</i> )-9-(2-Phosphonylmethoxypropyl)adenine

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Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

Jan Balzarini, Antonı́n Holý, Jindřich Jindřich et al. · Antimicrobial Agents and Chemotherapy · 1993 · 345 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.

Jan Balzarini, Lieve Naesens, Piet Herdewijn et al. · Proceedings of the National Academy of Sciences · 1989 · 218 citations · Full text

Medicine, Oncology, Pharmacology +11

Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients

K C Cundy, Patricia Barditch‐Crovo, Robert Walker et al. · Antimicrobial Agents and Chemotherapy · 1995 · 131 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +8

9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques

Koen K. A. Van Rompay, Julie M. Cherrington, Marta L. Marthas et al. · Antimicrobial Agents and Chemotherapy · 1996 · 108 citations · Full text

Life Sciences, Infectious Diseases, Pharmacology +16