Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome.

Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits

Cecilia M. Canessa, Laurent Schild, Gary Buell et al. · Nature · 1994 · 2K citations

Natural Sciences, Biochemistry, Biophysics +13

Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel

Richard A. Shimkets, David G. Warnock, Christopher M. Bositis et al. · Cell · 1994 · 1.3K citations

Life Sciences, Genetics, Molecular Genetics +15

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

Sibo Feng, James Chen, Hongtao Yu et al. · Science · 1994 · 807 citations

Life Sciences, Biochemistry, Molecular Biology +17

Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome

Joni H. Hansson, Carol Nelson‐Williams, Hiroshi Suzuki et al. · Nature Genetics · 1995 · 754 citations

Life Sciences, Genetics, Molecular Genetics +13

The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.

Hsin-Yu Chen, Marius Sudol · Proceedings of the National Academy of Sciences · 1995 · 567 citations

Life Sciences, Biochemistry, Molecular Biology +16