Inhibitory cross‐talk between the <scp>AMPK</scp> and <scp>ERK</scp> pathways mediates endoplasmic reticulum stress‐induced insulin resistance in skeletal muscle

Abstract

Inhibition of ERK signalling pathways by a chemical inhibitor and knockdown of ERK improved AMPK and Akt signallings and reversed ER stress-induced insulin resistance in L6 myotubes. These findings suggest that ERK signalling plays an important role in the regulation of insulin signals in muscle cells under ER stress.