Covariate effects and population pharmacokinetics of lamivudine in <scp>HIV</scp>‐infected children

Abstract

The use of meta-analysis is critical to identify the correct covariate-parameter relationships, which must be assessed before a model is applied for predictive purposes (e.g. defining dosing recommendations for children). In contrast to prior modelling efforts, we show that the covariate distribution in the target population must be considered.