Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

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The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10

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Pharmacy, Toxicology, Analytical Toxicology +10

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

Ruo Li Bai, Kenneth D. Paull, Cherry L. Herald et al. · Journal of Biological Chemistry · 1991 · 377 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal

Ruoli Bai, George R. Petit, Ernest Hamel · Biochemical Pharmacology · 1990 · 320 citations

Natural Sciences, Biochemistry, Marine Biology +11

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

R Bai, George R. Pettit, Ernest Hamel · Journal of Biological Chemistry · 1990 · 286 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17