Concepedia

Novel Experimental Parameters to Quantify the Modulation of Absorptive and Secretory Transport of Compounds by P-Glycoprotein in Cell Culture Models of Intestinal Epithelium

Matthew D. Troutman, Dhiren R. Thakker

Pharmaceutical Research · 2003 · 161 citations · 49 references

DOI

Concepts

References

49

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

, , +9

Goodman and Gilman's The Pharmacological Basis of Therapeutics

Robert C. Hastings, Gillis W. Long · JAMA · 1991 · 1.1K citations

, , +6

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

, , +17

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

Bernd Greiner, Michel Eichelbaum, Péter Fritz et al. · Journal of Clinical Investigation · 1999 · 920 citations · Full text

, , +9

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

Alex Sparreboom, Judith van Asperen, Ulrich Mayer et al. · Proceedings of the National Academy of Sciences · 1997 · 880 citations

, , +15