A Convenient Synthesis of N-Methoxy-N-Methylamides from Carboxylic Acids

Abstract

Abstract Carboxylic acids can be converted to their corresponding N-methoxy-N-methylamides in high yields using 2-chloro-1-methylpyridinium iodide as the coupling agent. The reaction proceeds without racemization when chiral carboxylic acids are used as the starting material.