Concepedia

Comparing The Effects of Small Molecules BIX-01294, Bay K8644, RG-108 and Valproic Acid, and Their Different Combinations on Induction of Pluripotency Marker-Genes by Oct4 in The Mouse Brain.

Sareh Asadi, Samaneh Dehghan, Maryam Hajikaram, Seyed Javad Mowla, Abolhassan Ahmadiani, Mohammad Javan

PubMed · 2015 · 10 citations · 11 references

Abstract

These results suggest VPA as the best enhancer of pluripotency among the chemicals tested, especially when applied prior to pluripotency induction by Oct4.

References

11

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

Kazutoshi Takahashi, Shinya Yamanaka · Cell · 2006 · 26.2K citations · Full text

Tissue Engineering, Regenerative Medicine, Defined Factors +14

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

Masato Nakagawa, Michiyo Koyanagi, Koji Tanabe et al. · Nature Biotechnology · 2007 · 2.8K citations

Tissue Engineering, Regenerative Medicine, Induced Pluripotent Stem Cell +12

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Martin Göttlicher · The EMBO Journal · 2001 · 1.9K citations · Full text

Hdac Inhibitors, Valproic Acid, Transformed Cells +10

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

Danwei Huangfu, René Maehr, Wenjun Guo et al. · Nature Biotechnology · 2008 · 1.6K citations · Full text

Tissue Engineering, Defined Factors, Induced Pluripotent Stem Cell +12

Oct4-Induced Pluripotency in Adult Neural Stem Cells

Jeong Beom Kim, Vittorio Sebastiano, Guangming Wu et al. · Cell · 2009 · 941 citations · Full text

Oct4-induced Pluripotency, Induced Pluripotent Stem Cell, Developmental Biology +6