Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

Danwei Huangfu, René Maehr, Wenjun Guo, +4

Nature Biotechnology

Tissue EngineeringDefined FactorsInduced Pluripotent Stem CellPluripotent Stem CellsEngineering +10

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

Danwei Huangfu, Kenji Osafune, René Maehr, +5

Nature Biotechnology

Regenerative MedicineInduced Pluripotent Stem CellDevelopmental BiologyPluripotent Stem CellsMedicine +7

Functional annotation of native enhancers with a Cas9–histone demethylase fusion

Nicola A. Kearns, Hannah Pham, Barbara Tabak, +4

Nature Methods

Histone ModificationsChromatinChromatin StructureChromatin RemodelingMedicine +13

Ultrastructural Details of Mammalian Chromosome Architecture

Nils Krietenstein, Sameer Abraham, Sergey V. Venev, +9

Molecular Cell

ChromatinChromatin StructureCytogeneticsGeneticsNuclear Organization +3

Generation of pluripotent stem cells from patients with type 1 diabetes

René Maehr, Shuibing Chen, Melinda Snitow, +5

Proceedings of the National Academy of Sciences

A small molecule that directs differentiation of human ESCs into the pancreatic lineage

Shuibing Chen, Malgorzata Borowiak, Julia L Fox, +8

Nature Chemical Biology

Lineage PlasticityCell LineageDevelopmental BiologyTissue DevelopmentHuman Cell +6

Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells

Malgorzata Borowiak, René Maehr, Shuibing Chen, +5

Cell stem cell

Regenerative MedicineTissue EngineeringInduced Pluripotent Stem CellDevelopmental BiologyCell Specialization +7

Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells

Nicola A. Kearns, Ryan M. Genga, Metewo Selase Enuameh, +3

Development

Dcas9 EffectorsTranscriptional RegulationCas9 Effector-mediated RegulationStem CellsCell Differentiation Status +14

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

Thomas F. Westbrook, Guang Hu, Xiaolu L. Ang, +8

Nature

NeuroregenerationSignal TransductionNeuroscienceCell BiologyMolecular Neurobiology +5

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal

Kathy K. Niakan, Hongkai Ji, René Maehr, +9

Genes & Development