Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

Two-Photon Laser Scanning Fluorescence Microscopy

Winfried Denk, James H. Strickler, Watt W. Webb · Science · 1990 · 9.3K citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Neurodegenerative Diseases, Alzheimer's Disease, Immunology +7

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Dora Games, David S. Adams, Ree Alessandrini et al. · Nature · 1995 · 2.5K citations

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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Frédérique Bard, Catherine Cannon, Robin Barbour et al. · Nature Medicine · 2000 · 2K citations · Full text

Amyloid β-Peptide Enter, Neurodegenerative Diseases, Alzheimer's Disease +13

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

Teresa Gómez‐Isla, Joseph L. Price, Daniel W. McKeel et al. · Journal of Neuroscience · 1996 · 1.8K citations · Full text