Concepedia

Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis

Xilong Ou, Zhenxing Cheng, Tingting Liu, Zhongming Tang, Wei Huang, Peter Szatmary, Shuyun Zheng, Robert Sutton, Cheng‐Hock Toh, Nan Zhang,

Pancreas · 2015 · 38 citations · 31 references

DOI

Abstract

Circulating histones increased significantly in necrotizing pancreatitis due to extensive pancreatic acinar cell death. Levels of circulating histones may have translational potential as a biomarker of disease severity.

References

31

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Karolin Luger, Armin W. Mäder, Robin K. Richmond et al. · Nature · 1997 · 9.3K citations

Nucleosome Core Particle, Crystal Structure, Engineering +10

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Qin Zhang, Mustafa Raoof, Yu Chen et al. · Nature · 2010 · 3.6K citations · Full text

Mechanobiology, Inflammation, Mitochondrial Biogenesis +6

American College of Gastroenterology Guideline: Management of Acute Pancreatitis

Scott Tenner, John Baillie, John M. DeWitt et al. · The American Journal of Gastroenterology · 2013 · 2.3K citations

Critical Care Management, Infected Necrosis, Pancreatic Fluid Collection +10

Extracellular histones are major mediators of death in sepsis

Jun Xu, Xiaomei Zhang, Rosana Pelayo et al. · Nature Medicine · 2009 · 1.5K citations · Full text

Inflammation, Apoptosis, Immunology +6

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

Hong Wang, Hong Liao, Mahendar Ochani et al. · Nature Medicine · 2004 · 1.2K citations

Inflammation, Experimental Sepsis, Disease Pathophysiology +7