Concepedia

Use of long-term cultures of human hepatocytes to study cytochrome P450 gene expression

Lydiane Pichard‐Garcia, Sabine Gerbal‐Chaloin, Jean-Bernard Ferrini, Jean‐Michel Fabre, Patrick Maurel

Methods in enzymology on CD-ROM/Methods in enzymology · 2002 · 76 citations · 17 references

DOI

Concepts

References

17

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

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An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

, , +16

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

Tatsuya Sueyoshi, Takeshi Kawamoto, Igor N. Zelko et al. · Journal of Biological Chemistry · 1999 · 671 citations · Full text

, , +17

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

Lydiane Pichard, Isabelle Fabre, Gérard Fabre et al. · Drug Metabolism and Disposition · 1990 · 437 citations

, , +17

Dexamethasone Induces Pregnane X Receptor and Retinoid X Receptor-α Expression in Human Hepatocytes: Synergistic Increase of CYP3A4 Induction by Pregnane X Receptor Activators

Jean‐Marc Pascussi, Lionel Drocourt, Jean‐Michel Fabre et al. · Molecular Pharmacology · 2000 · 367 citations

, , +11