Concepedia

Computational approaches to natural product discovery

Marnix H. Medema, Michael A. Fischbach

Nature Chemical Biology · 2015 · 490 citations · 77 references

Open access

Concepts

PharmacyChemistryMedicinal ChemistryComputational BiologyComputational ChemistryDrug DiscoveryBioactive Natural ProductsChemical Space ExplorationComputational Drug DiscoveryNatural Product Drug DiscoveryNatural Product RepurposingNatural Product-based Drug DesignCheminformatics For Natural ProductsChemoinformatics For Natural ProductsComputational Natural Product DesignGenome-enabled Natural Product DiscoveryNatural Product Library Screening

References

77

BLAST+: architecture and applications

Christiam Camacho, George Coulouris, Vahram Avagyan et al. · BMC Bioinformatics · 2009 · 23.2K citations · Full text

Life Sciences, Bioinformatics, Biology +13

The Pfam Protein Families Database

Alex Bateman · Nucleic Acids Research · 2002 · 14.2K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +16

MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct <i>de Bruijn</i> graph

Dinghua Li, Chi-Man Liu, Ruibang Luo et al. · Bioinformatics · 2015 · 10K citations · Full text

Life Sciences, Bioinformatics, Genome Assembly +11

Accelerated Profile HMM Searches

Sean R. Eddy · PLoS Computational Biology · 2011 · 7.5K citations · Full text

Life Sciences, Bioinformatics, Computer Science +17

Versatile and open software for comparing large genomes

Stefan Kurtz, Adam M. Phillippy, Arthur L. Delcher et al. · Genome biology · 2004 · 5.8K citations · Full text

Life Sciences, Bioinformatics, Evolutionary Biology +17