Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo

Origin of the West Nile Virus Responsible for an Outbreak of Encephalitis in the Northeastern United States

Robert S. Lanciotti, John T. Roehrig, Vincent Deubel et al. · Science · 1999 · 1.6K citations

Pathology, Envelope Glycoprotein, Virus Transmission +16

Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population

Marco Vignuzzi, Jeffrey K. Stone, Jamie J. Arnold et al. · Nature · 2005 · 1.1K citations · Full text

Biology, Viral Evolution, Viral Population +10

The evolutionary biology of viruses

Paul Harvey · Trends in Ecology & Evolution · 1994 · 440 citations

Viral Evolution, Evolutionary Biology, Pathogenesis +4

Increased Fidelity Reduces Poliovirus Fitness and Virulence under Selective Pressure in Mice

Julie K. Pfeiffer, Karla Kirkegaard · PLoS Pathogens · 2005 · 382 citations · Full text

Viral Replication, Synthetic Virology, Viral Pathogenesis +16

Engineering attenuated virus vaccines by controlling replication fidelity

Marco Vignuzzi, Emily Wendt, Raul Andino · Nature Medicine · 2008 · 277 citations · Full text

Vaccination, Vaccine Development, Immunology +5