Pharminox (United Kingdom)

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

Angela Rizzo, Sara Iachettini, Pasquale Zizza et al. · Journal of Experimental & Clinical Cancer Research · 2014 · 40 citations · Full text

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

Sara Iachettini, Malcolm F. G. Stevens, Mark Frigerio et al. · Journal of Experimental & Clinical Cancer Research · 2013 · 33 citations · Full text

Certain Imidazotetrazines Escape O6-Methylguanine-DNA Methyltransferase and Mismatch Repair

Jihong Zhang, Malcolm F. G. Stevens, Marc Hummersone et al. · Oncology · 2011 · 26 citations · Full text

N3-Substituted Temozolomide Analogs Overcome Methylguanine-DNA Methyltransferase and Mismatch Repair Precipitating Apoptotic and Autophagic Cancer Cell Death

Jihong Zhang, Marc Hummersone, Charles S. Matthews et al. · Oncology · 2014 · 25 citations

Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines

David Cousin, Jihong Zhang, Marc Hummersone et al. · MedChemComm · 2016 · 19 citations · Full text

Neuro-oncology, Medicinal Chemistry, Glioma +15