Concepedia

Xlf-cernunnos

XLF-Cernunnos is a eukaryotic DNA repair protein that belongs to the non-homologous end joining (NHEJ) pathway and specifically functions as a cofactor in bridging and stabilizing the interaction between XRCC4 and DNA ligase IV to facilitate efficient ligation of double-strand DNA breaks.

26

Publications

2.6K

Citations

151

Authors

82

Institutions

Publications per year

2017–2026

1

Variants

Nhej1Xlf

Parents

Publications

26

Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly

Dietke Buck, Laurent Malivert, Régina de Chasseval et al. · Cell · 2006 · 702 citations · Full text

, , +11

Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination

Gang� Li, Frederick W. Alt, Hwei-Ling Cheng et al. · Molecular Cell · 2008 · 190 citations · Full text

, , +14

Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

Chun J. Tsai, Sunny A. Kim, Gilbert Chu · Proceedings of the National Academy of Sciences · 2007 · 184 citations

, , +17

Structural characterization of filaments formed by human Xrcc4–Cernunnos/XLF complex involved in nonhomologous DNA end-joining

Virginie Ropars, Pascal Drevet, Pierre Legrand et al. · Proceedings of the National Academy of Sciences · 2011 · 138 citations

, , +17

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence

Jiafeng Gu, Haihui Lu, Albert G. Tsai et al. · Nucleic Acids Research · 2007 · 129 citations · Full text

, , +16

1–5 of 26

Authors

151

  1. PR
    Patrick Revy

    Inserm, France

    9 publications · 1.1K citations

    9

    h-index

  2. JD
    Jean‐Pierre de Villartay

    Inserm, France

    8 publications · 1.1K citations

    8

    h-index

  3. LM
    Laurent Malivert

    Hôpital Necker-Enfants Malades, France

    4 publications · 833 citations

    4

    h-index

  4. MR
    Michael R. Lieber

    University of Southern California, United States

    3 publications · 333 citations

    3

    h-index

  5. IC
    Isabelle Callebaut

    Centre National de la Recherche Scientifique, France

    3 publications · 208 citations

    3

    h-index

1–5 of 151

Institutions

82

  1. Inserm

    Paris, France

    9 h-index

    33 publications

    7.7K citations

  2. Université Paris Cité

    Paris, France

    7 h-index

    29 publications

    7.5K citations

  3. Délégation Paris 5

    Paris, France

    6 h-index

    22 publications

    7.2K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    22 publications

    1.5K citations

  5. Hôpital Necker-Enfants Malades

    Paris, France

    5 h-index

    21 publications

    6.7K citations

  6. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    21 publications

    1.5K citations

  7. University of Sussex

    Brighton, United Kingdom

    4 h-index

    13 publications

    1.2K citations

  8. Radiation Oncology Associates

    Fort Wayne, United States

    3 h-index

    4 publications

    276 citations

1–8 of 82

Venues

  1. Journal of Biological Chemistry

    JBC · 4 publications · 301 citations

    4

    h-index

  2. Nucleic Acids Research

    3 publications · 287 citations

    3

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 413 citations

    3

    h-index

  4. Stem Cells

    1 publications · 16 citations

    1

    h-index

  5. Genetics

    1 publications · 21 citations

    1

    h-index

1–5