Concepedia

Variable Region Engineering

Variable Region Engineering is a methodological approach in antibody design that involves the targeted modification of the antigen-binding domains of immunoglobulins to enhance specificity, affinity, or stability, distinguishing it from broader antibody optimization strategies by focusing exclusively on the variable regions responsible for molecular recognition.

24

Publications

3.2K

Citations

126

Authors

38

Institutions

Publications per year

2017–2026

3

Parents

Publications

24

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

James S. Huston, Dennis J. Levinson, M Mudgett-Hunter et al. · Proceedings of the National Academy of Sciences · 1988 · 1.6K citations · Full text

, , +17

Reduced elimination of IgG antibodies by engineering the variable region

Tomoyuki Igawa, Hiroyuki Tsunoda, Tatsuhiko Tachibana et al. · Protein Engineering Design and Selection · 2010 · 262 citations

, , +17

Novel vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction

M. Josefina Coloma, Alice Hastings, Letitia A. Wims et al. · Journal of Immunological Methods · 1992 · 179 citations

, , +13

High-level expression of chimeric antibodies using adapted cDNA variable region cassettes

Stephen D. Gillies, Kin-Ming Lo, John S. Wesolowski · Journal of Immunological Methods · 1989 · 161 citations

, , +16

Pharmacokinetics and biodistribution of genetically-engineered antibodies.

David Colcher, Gabriela Pavlínková, Guy Beresford et al. · PubMed · 1998 · 142 citations

, , +17

1–5 of 24

Authors

126

  1. BJ
    Barbara J.M. Booth

    University of Nebraska Medical Center, United States

    2 publications · 251 citations

    2

    h-index

  2. GP
    Gabriela Pavlínková

    Czech Academy of Sciences, Institute of Biotechnology, Czechia

    2 publications · 251 citations

    2

    h-index

  3. GB
    Guy Beresford

    Emory University, United States

    2 publications · 251 citations

    2

    h-index

  4. DC
    David Colcher

    National Cancer Institute, United States

    2 publications · 251 citations

    2

    h-index

  5. SK
    Surinder K. Batra

    University of Nebraska Medical Center, United States

    2 publications · 251 citations

    2

    h-index

1–5 of 126

Institutions

38

  1. University of Nebraska Medical Center

    Omaha, United States

    2 h-index

    9 publications

    1.1K citations

  2. University of California, Los Angeles

    Los Angeles, United States

    2 h-index

    4 publications

    550 citations

  3. Pennsylvania State University

    State College, United States

    2 h-index

    6 publications

    420 citations

  4. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    4 publications

    211 citations

  5. University College London

    London, United Kingdom

    1 h-index

    3 publications

    135 citations

  6. The University of Tokyo

    Tokyo, Japan

    1 h-index

    1 publications

    20 citations

  7. National Cancer Institute

    Bethesda, United States

    1 h-index

    4 publications

    316 citations

  8. Fukuoka University

    Fukuoka, Japan

    1 h-index

    1 publications

    15 citations

1–8 of 38

Venues

  1. PubMed

    Repository · 3 publications · 266 citations

    3

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 1.7K citations

    2

    h-index

  3. Journal of Immunological Methods

    2 publications · 340 citations

    2

    h-index

  4. Protein Engineering Design and Selection

    PEDS · 2 publications · 280 citations

    2

    h-index

  5. Journal of Biological Chemistry

    JBC · 2 publications · 48 citations

    2

    h-index

1–5