Concepedia

Variable (V) Gene Segment Selection

Variable (V) Gene Segment Selection is a genetic recombination process in developing B cells that constitutes a mechanism within adaptive immunity by determining the variable region of immunoglobulin heavy or light chains through the site-specific, irreversible joining of one variable (V) gene segment to a diversity (D) or joining (J) segment, thereby generating combinatorial diversity essential for antigen receptor specificity.

13

Publications

487

Citations

53

Authors

21

Institutions

Publications per year

2017–2026

0

Parents

Publications

13

Influence of Clonal Selection on the Expression of Immunoglobulin Variable Region Genes

Tim Manser, Shuying Huang, Malcolm L. Gefter · Science · 1984 · 119 citations

, , +17

V‐region directed selection in differentiating B lymphocytes.

François Huetz, Leif Carlsson, Ulla‐Carin Tornberg et al. · The EMBO Journal · 1993 · 87 citations

, , +12

Unifying model for molecular determinants of the preselection Vβ repertoire

Suhasni Gopalakrishnan, Kinjal Majumder, Alexander V. Predeus et al. · Proceedings of the National Academy of Sciences · 2013 · 56 citations · Full text

, , +17

Antibodies that are specific for a single amino acid interchange in a protein epitope use structurally distinct variable regions.

S E Stark, A J Caton · The Journal of Experimental Medicine · 1991 · 41 citations · Full text

, , +17

Conservation of the most JH proximal Ig VH gene segment (VHVI) throughout primate evolution

K Meek, T. EVERSOLE, J. Donald Capra · The Journal of Immunology · 1991 · 34 citations

, , +15

1–5 of 13

Authors

53

  1. TM
    Tim Manser

    Thomas Jefferson University, United States

    2 publications · 136 citations

    2

    h-index

  2. LJ
    Lawrence J. Wysocki

    University of Colorado Denver, United States

    2 publications · 41 citations

    2

    h-index

  3. ML
    M L Gefter

    Massachusetts Institute of Technology, United States

    2 publications · 41 citations

    2

    h-index

  4. DS
    Daniel S. Wechsler

    Duke Medical Center, United States

    1 publications · 24 citations

    1

    h-index

  5. KA
    Karvonen

    University of Oulu, Finland

    1 publications · 14 citations

    1

    h-index

1–5 of 53

Institutions

21

  1. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    14 publications

    498 citations

  2. Harvard University

    Cambridge, United States

    2 h-index

    10 publications

    216 citations

  3. Beth Israel Deaconess Medical Center

    Boston, United States

    1 h-index

    2 publications

    24 citations

  4. Institut Necker Enfants Malades

    Paris, France

    1 h-index

    3 publications

    63 citations

  5. Washington University in St. Louis

    St Louis, United States

    1 h-index

    7 publications

    392 citations

  6. University of Virginia

    Charlottesville, United States

    1 h-index

    1 publications

    15 citations

  7. The Wistar Institute

    Philadelphia, United States

    1 h-index

    2 publications

    82 citations

  8. Massachusetts General Hospital

    Boston, United States

    1 h-index

    8 publications

    192 citations

1–8 of 21

Venues

  1. The Journal of Immunology

    JI · 4 publications · 96 citations

    4

    h-index

  2. Scandinavian Journal of Immunology

    2 publications · 31 citations

    2

    h-index

  3. Virology

    1 publications · 15 citations

    1

    h-index

  4. PLoS ONE

    1 publications · 12 citations

    1

    h-index

  5. The Journal of Experimental Medicine

    1 publications · 41 citations

    1

    h-index

1–5