Concepedia

Use-dependent Block

Use-Dependent Block is a pharmacological phenomenon in which the inhibitory effect of a ligand on an ion channel increases with the frequency or activity of channel gating, distinguishing it from static or voltage-dependent block by its reliance on operational usage.

189

Publications

11.6K

Citations

579

Authors

186

Institutions

Publications per year

2017–2026

4

Variants

Use-dependent Inhibition

Parents

Publications

189

Molecular Determinants of State-Dependent Block of Na <sup>+</sup> Channels by Local Anesthetics

David S. Ragsdale, Jancy C. McPhee, Todd Scheuer et al. · Science · 1994 · 861 citations

, , +17

Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.

Michael C. Sanguinetti, Robert S. Kass · Circulation Research · 1984 · 550 citations · Full text

, , +17

Atrium-Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation

Alexander Burashnikov, José M. Di Diego, Andrew C. Zygmunt et al. · Circulation · 2007 · 400 citations · Full text

, , +17

Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine

John F. MacDonald, Željka Miljković, Peter Pennefather · Journal of Neurophysiology · 1987 · 390 citations

, , +17

Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics

C F Starmer, Augustus O. Grant, Harold C. Strauss · Biophysical Journal · 1984 · 341 citations · Full text

, , +17

1–5 of 189

Authors

579

  1. DC
    Diana Conte Camerino

    University of Bari Aldo Moro, Italy

    9 publications · 260 citations

    9

    h-index

  2. CF
    Carlo Franchini

    University of Bari Aldo Moro, Italy

    8 publications · 246 citations

    8

    h-index

  3. AD
    Annamaria De Luca

    University of Bari Aldo Moro, Italy

    8 publications · 241 citations

    8

    h-index

  4. CW
    C W Clarkson

    Tulane University, United States

    7 publications · 285 citations

    7

    h-index

  5. GK
    Ging Kuo Wang

    Brigham and Women's Hospital, United States

    7 publications · 381 citations

    7

    h-index

1–5 of 579

Institutions

186

  1. University of Bari Aldo Moro

    Bari, Italy

    10 h-index

    66 publications

    1.9K citations

  2. Vanderbilt University

    Nashville, United States

    8 h-index

    14 publications

    1K citations

  3. Harvard University

    Cambridge, United States

    7 h-index

    13 publications

    624 citations

  4. Brigham and Women's Hospital

    Boston, United States

    7 h-index

    11 publications

    499 citations

  5. Duke Medical Center

    Durham, United States

    6 h-index

    23 publications

    2K citations

  6. Tulane University

    New Orleans, United States

    6 h-index

    12 publications

    479 citations

  7. University of Chicago

    Chicago, United States

    6 h-index

    17 publications

    891 citations

  8. University of Washington

    Seattle, United States

    6 h-index

    24 publications

    6K citations

1–8 of 186

Venues

  1. Circulation Research

    19 publications · 1.7K citations

    17

    h-index

  2. 16

    h-index

  3. The Journal of General Physiology

    JGP · 15 publications · 1.4K citations

    15

    h-index

  4. Molecular Pharmacology

    16 publications · 796 citations

    13

    h-index

  5. Journal of Cardiovascular Pharmacology

    13 publications · 227 citations

    11

    h-index

1–5