Concepedia

Twinkle Helicase

Twinkle Helicase is a mitochondrial DNA helicase enzyme that catalyzes the unwinding of double-stranded mitochondrial DNA during replication and repair, distinguished by its intrinsic 5′ to 3′ directionality and essential role in maintaining mitochondrial DNA copy number homeostasis.

55

Publications

4.7K

Citations

308

Authors

141

Institutions

Publications per year

2017–2026

13

Variants

C10orf2Peo1Twnk

Parents

Publications

55

Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice

Henna Tyynismaa, Katja Peltola Mjøsund, Sjoerd Wanrooij et al. · Proceedings of the National Academy of Sciences · 2005 · 335 citations · Full text

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TWINKLE Has 5′ → 3′ DNA Helicase Activity and Is Specifically Stimulated by Mitochondrial Single-stranded DNA-binding Protein

Jenny Korhonen, Martina Gaspari, Maria Falkenberg · Journal of Biological Chemistry · 2003 · 300 citations · Full text

, , +17

Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number

Henna Tyynismaa, Hiroshi Sembongi, Monika Bokori-Brown et al. · Human Molecular Genetics · 2004 · 244 citations · Full text

, , +17

Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion

Anna H. Hakonen, Pirjo Isohanni, Anders Paetau et al. · Brain · 2007 · 197 citations · Full text

, , +17

Human Dna2 Is a Nuclear and Mitochondrial DNA Maintenance Protein

Julien P. Duxin, Benjamin Dao, Peter Martinsson et al. · Molecular and Cellular Biology · 2009 · 184 citations · Full text

, , +17

1–5 of 55

Authors

308

  1. JN
    Johannes N. Spelbrink

    12 publications · 1.7K citations

    12

    h-index

  2. AS
    Anu Suomalainen

    University of Helsinki, Finland

    10 publications · 1.4K citations

    10

    h-index

  3. MF
    Maria Falkenberg

    University of Gothenburg, Sweden

    8 publications · 829 citations

    8

    h-index

  4. HT
    Henna Tyynismaa

    University of Helsinki, Finland

    5 publications · 885 citations

    5

    h-index

  5. SG
    Steffi Goffart

    University of Eastern Finland, Finland

    5 publications · 627 citations

    5

    h-index

1–5 of 308

Institutions

141

  1. University of Helsinki

    Helsinki, Finland

    11 h-index

    32 publications

    5.7K citations

  2. Tampere University Hospital

    Tampere, Finland

    9 h-index

    29 publications

    5.8K citations

  3. Helsinki University Hospital

    Helsinki, Finland

    7 h-index

    22 publications

    4.9K citations

  4. Radboud University Nijmegen

    Nijmegen, The Netherlands

    6 h-index

    18 publications

    1.3K citations

  5. Radboud University Medical Center

    Nijmegen, The Netherlands

    6 h-index

    18 publications

    1.3K citations

  6. Tampere University

    Tampere, Finland

    5 h-index

    12 publications

    816 citations

  7. Karolinska Institutet

    Stockholm, Sweden

    5 h-index

    17 publications

    2.1K citations

  8. University of Gothenburg

    Gothenburg, Sweden

    5 h-index

    25 publications

    2K citations

1–8 of 141

Venues

  1. Nucleic Acids Research

    12 publications · 822 citations

    12

    h-index

  2. Journal of Biological Chemistry

    JBC · 10 publications · 934 citations

    10

    h-index

  3. Human Molecular Genetics

    6 publications · 735 citations

    6

    h-index

  4. PLoS ONE

    5 publications · 265 citations

    5

    h-index

  5. Molecular and Cellular Biology

    MCB · 3 publications · 345 citations

    3

    h-index

1–5