Concepedia

Tumor-bone Microenvironment

The Tumor-Bone Microenvironment is a specialized niche within the skeletal system characterized by dynamic interactions between metastatic tumor cells and indigenous bone cells, including osteoblasts, osteoclasts, and stromal elements, which collectively mediate tumor colonization, survival, and pain-inducing bone remodeling processes.

759

Publications

47.2K

Citations

4.9K

Authors

1.2K

Institutions

Publications per year

2017–2026

262

Parents

Publications

759

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

Chand Khanna, Xiaolin Wan, Seuli Bose et al. · Nature Medicine · 2004 · 718 citations

, , +12

Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma

Yan Zhou, Yang Dong, Qingcheng Yang et al. · Nature Communications · 2020 · 687 citations · Full text

, , +17

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

Xiang H.-F. Zhang, Qiongqing Wang, William L. Gerald et al. · Cancer Cell · 2009 · 658 citations · Full text

, , +16

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

Simone Bersini, Jessie S. Jeon, Gabriele Dubini et al. · Biomaterials · 2014 · 523 citations · Full text

, , +16

Tumor-Infiltrating Macrophages Are Associated with Metastasis Suppression in High-Grade Osteosarcoma: A Rationale for Treatment with Macrophage Activating Agents

Emilie P. Buddingh, Marieke L. Kuijjer, R.A.J. Duim et al. · Clinical Cancer Research · 2011 · 510 citations · Full text

, , +17

1–5 of 759

Authors

4.9K

  1. KJ
    Kenneth J. Pienta

    University of Michigan, United States

    13 publications · 1K citations

    13

    h-index

  2. IH
    Ingunn Holen

    University of Sheffield, United Kingdom

    12 publications · 774 citations

    12

    h-index

  3. CC
    Conor C. Lynch

    Moffitt Cancer Center, United States

    11 publications · 855 citations

    11

    h-index

  4. CJ
    Christopher J. Logothetis

    The University of Texas MD Anderson Cancer Center, United States

    10 publications · 715 citations

    10

    h-index

  5. DW
    Dietmar W. Hutmacher

    Queensland University of Technology, Australia

    10 publications · 514 citations

    10

    h-index

1–5 of 4.9K

Institutions

1.2K

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    28 h-index

    199 publications

    13K citations

  2. University of Michigan

    Ann Arbor, United States

    25 h-index

    169 publications

    14.7K citations

  3. Baylor College of Medicine

    Houston, United States

    21 h-index

    156 publications

    18.9K citations

  4. University of Sheffield

    Sheffield, United Kingdom

    18 h-index

    112 publications

    9.8K citations

  5. Inserm

    Paris, France

    16 h-index

    118 publications

    4.8K citations

  6. Harvard University

    Cambridge, United States

    15 h-index

    125 publications

    21K citations

  7. Istituti di Ricovero e Cura a Carattere Scientifico

    Rome, Italy

    14 h-index

    64 publications

    4.8K citations

  8. Vanderbilt University

    Nashville, United States

    14 h-index

    42 publications

    4.6K citations

1–8 of 1.2K

Venues

  1. Cancer Research

    35 publications · 3.6K citations

    33

    h-index

  2. PubMed

    Repository · 35 publications · 2.5K citations

    23

    h-index

  3. Bone

    25 publications · 1.1K citations

    21

    h-index

  4. Clinical & Experimental Metastasis

    30 publications · 1.3K citations

    21

    h-index

  5. PLoS ONE

    20 publications · 1K citations

    17

    h-index

1–5