Concepedia

Tryptophan Hydroxylation

Tryptophan Hydroxylation is a biochemical transformation reaction in which the essential amino acid tryptophan is specifically hydroxylated at the 5-position of its indole ring by the enzyme tryptophan hydroxylase, forming 5-hydroxytryptophan as the rate-limiting step in serotonin biosynthesis.

1.4K

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77.2K

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5.1K

Authors

1.3K

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Publications per year

2017–2026

142

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Publications

1.4K

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

Catherine Uyttenhove, Luc Pilotte, Ivan Théate et al. · Nature Medicine · 2003 · 2.3K citations

, , +11

A Role for Flavin Monooxygenase-Like Enzymes in Auxin Biosynthesis

Yunde Zhao, S. Christensen, Christian Fankhauser et al. · Science · 2001 · 1.2K citations

, , +17

Platelet-Derived Serotonin Mediates Liver Regeneration

Mickaël Lesurtel, Rolf Graf, Boris Aleil et al. · Science · 2006 · 777 citations

, , +17

Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

Patrick Hwu, Mark Du, Réjean Lapointe et al. · The Journal of Immunology · 2000 · 742 citations · Full text

, , +15

A unique central tryptophan hydroxylase isoform

Diego J. Walther, Michael Bäder · Biochemical Pharmacology · 2003 · 737 citations

, , +12

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Authors

5.1K

  1. DF
    Dietmar Fuchs

    Innsbruck Medical University, Austria

    25 publications · 2K citations

    20

    h-index

  2. WL
    Walter Lovenberg

    National Heart Lung and Blood Institute, United States

    20 publications · 1.9K citations

    17

    h-index

  3. GR
    Glen R. Hanson

    University of Utah, United States

    15 publications · 919 citations

    14

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  4. MC
    Margaret C. Boadle‐Biber

    Virginia Commonwealth University Medical Center, United States

    16 publications · 647 citations

    14

    h-index

  5. JW
    James W. Gibb

    University of Utah, United States

    15 publications · 859 citations

    14

    h-index

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Institutions

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  1. National Institutes of Health

    Bethesda, United States

    28 h-index

    120 publications

    10K citations

  2. Inserm

    Paris, France

    22 h-index

    201 publications

    12.2K citations

  3. National Institute of Mental Health

    Bethesda, United States

    21 h-index

    59 publications

    4.1K citations

  4. National Heart Lung and Blood Institute

    Bethesda, United States

    19 h-index

    68 publications

    6.8K citations

  5. Innsbruck Medical University

    Innsbruck, Austria

    19 h-index

    71 publications

    5.3K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    91 publications

    2.9K citations

  7. Karolinska Institutet

    Stockholm, Sweden

    17 h-index

    57 publications

    2.8K citations

  8. Kyoto University

    Kyoto, Japan

    16 h-index

    80 publications

    3.3K citations

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  1. Journal of Neurochemistry

    JNC · 68 publications · 3.4K citations

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  2. Biochemical Pharmacology

    51 publications · 2.8K citations

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  3. Brain Research

    47 publications · 2.6K citations

    28

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  4. Journal of Biological Chemistry

    JBC · 29 publications · 2.2K citations

    24

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  5. PubMed

    Repository · 42 publications · 1.8K citations

    21

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