Concepedia

Transporter-mediated Interaction Modeling

Transporter-Mediated Interaction Modeling is a computational or mathematical framework within drug interaction modeling that specifically characterizes the dynamic influence of membrane transporters on the pharmacokinetic interactions between drugs by quantifying their combined effects on transporter inhibition, induction, or competition.

16

Publications

609

Citations

63

Authors

36

Institutions

Publications per year

2017–2026

10

Parents

Publications

16

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions

Maria Karlgren, Gustav Ahlin, Christel A. S. Bergström et al. · Pharmaceutical Research · 2011 · 119 citations · Full text

, , +17

Mechanistic Modeling to Predict the Transporter- and Enzyme-Mediated Drug-Drug Interactions of Repaglinide

Manthena V. S. Varma, Yurong Lai, Emi Kimoto et al. · Pharmaceutical Research · 2013 · 102 citations

, , +14

How Dopamine Transporter Interacts with Dopamine: Insights from Molecular Modeling and Simulation

Xiaoqin Huang, Chang‐Guo Zhan · Biophysical Journal · 2007 · 89 citations · Full text

, , +14

Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide

Manthena V. S. Varma, Renato J. Scialis, Jian Lin et al. · The AAPS Journal · 2014 · 56 citations · Full text

, , +16

Investigating Transporter‐Mediated Drug‐Drug Interactions Using a Physiologically Based Pharmacokinetic Model of Rosuvastatin

Qiuye Wang, Ming Zheng, Tarek A. Leil · CPT Pharmacometrics & Systems Pharmacology · 2017 · 40 citations · Full text

, , +17

1–5 of 16

Authors

63

  1. YS
    Yuichi Sugiyama

    The University of Tokyo, Japan

    3 publications · 83 citations

    3

    h-index

  2. KT
    Kota Toshimoto

    Seoul National University, South Korea

    3 publications · 83 citations

    3

    h-index

  3. SK
    Soojin Kim

    University of British Columbia, Canada

    2 publications · 44 citations

    2

    h-index

  4. YY
    Yoshiaki Yao

    Kyoto University Hospital, Japan

    2 publications · 44 citations

    2

    h-index

  5. MV
    Manthena V. S. Varma

    Pfizer (United States), United States

    2 publications · 158 citations

    2

    h-index

1–5 of 63

Institutions

36

  1. AstraZeneca (Sweden)

    Södertälje, Sweden

    2 h-index

    2 publications

    136 citations

  2. Astellas Pharma (Japan)

    Tokyo, Japan

    2 h-index

    6 publications

    132 citations

  3. Pfizer (United States)

    New York, United States

    2 h-index

    13 publications

    1K citations

  4. Université Claude Bernard Lyon 1

    Villeurbanne, France

    2 h-index

    10 publications

    110 citations

  5. Uppsala University

    Uppsala, Sweden

    1 h-index

    5 publications

    595 citations

  6. Hôpital de la Croix-Rousse

    Lyon, France

    1 h-index

    1 publications

    11 citations

  7. Texas Tech University Health Sciences Center

    Lubbock, United States

    1 h-index

    4 publications

    40 citations

  8. Bristol-Myers Squibb (Germany)

    Munich, Germany

    1 h-index

    3 publications

    120 citations

1–8 of 36

Venues

  1. Pharmaceutical Research

    2 publications · 221 citations

    2

    h-index

  2. The AAPS Journal

    AAPSJ · 1 publications · 56 citations

    2

    h-index

  3. CPT Pharmacometrics & Systems Pharmacology

    PSP · 2 publications · 79 citations

    2

    h-index

  4. Clinical Pharmacokinetics

    1 publications · 11 citations

    1

    h-index

  5. Methods in molecular biology

    Book series · 1 publications · 12 citations

    1

    h-index

1–5